Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

K Labib; J F Diffley

doi:10.1016/s0959-437x(00)00158-1

Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

Curr Opin Genet Dev. 2001 Feb;11(1):64-70. doi: 10.1016/s0959-437x(00)00158-1.

Authors

K Labib¹, J F Diffley

Affiliation

¹ Chromosome Replication Laboratory, ICRF Clare Hall Laboratories, Blanche Lane, South Mimms, EN6 3LD, Hertfordshire, UK.labib@icrf.icnet.uk

PMID: 11163153
DOI: 10.1016/s0959-437x(00)00158-1

Abstract

The MCM2-7 complex is essential for both the initiation and elongation phases of eukaryotic chromosome replication. There is some evidence that MCM2-7 proteins may act as a DNA helicase; at the same time, a variety of other DNA helicases have also been implicated in the replication of eukaryotic chromosomes.

Publication types

Review

MeSH terms

Adenosine Triphosphatases / metabolism
Cell Cycle Proteins / metabolism*
DNA Helicases / metabolism*
DNA Replication*
Escherichia coli / genetics
Escherichia coli / metabolism
Eukaryotic Cells / metabolism*
Protein Binding
RecQ Helicases
Saccharomyces cerevisiae Proteins*
Yeasts / genetics
Yeasts / metabolism

Substances

Cell Cycle Proteins
Saccharomyces cerevisiae Proteins
Adenosine Triphosphatases
PIF1 protein, S cerevisiae
RecQ protein, E coli
DNA Helicases
DNA2 protein, S cerevisiae
RecQ Helicases