Abstract
20-30% of gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated with Helicobacter pylori do not regress after antibiotic therapy. Regression can be assessed only by extended follow-up. To assess whether t(11;18, q21;q21), which results in a chimeric transcript between the AP12 and MLT genes, predicts lymphoma resistance to antibiotic therapy, we screened for the fusion transcript with RT-PCR in ten responsive and 12 non-responsive gastric MALT lymphomas. The AP12-MLT transcript was detected in nine (75%) of 12 patients non-responsive to antibiotic therapy but not in responsive patients. Most H pylori-associated gastric MALT lymphomas that do not respond to antibiotic therapy are associated with t(11;18, q21;q21).
MeSH terms
-
Adult
-
Aged
-
Anti-Bacterial Agents / therapeutic use
-
Chromosomes, Human, Pair 11 / genetics
-
Chromosomes, Human, Pair 18 / genetics
-
Drug Resistance, Neoplasm
-
Female
-
Helicobacter Infections / drug therapy*
-
Helicobacter Infections / microbiology
-
Helicobacter pylori / drug effects*
-
Humans
-
Lymphoma, B-Cell, Marginal Zone / drug therapy
-
Lymphoma, B-Cell, Marginal Zone / genetics*
-
Lymphoma, B-Cell, Marginal Zone / microbiology
-
Male
-
Middle Aged
-
Oncogene Proteins, Fusion / genetics
-
RNA, Neoplasm / genetics
-
RNA, Neoplasm / metabolism
-
Reverse Transcriptase Polymerase Chain Reaction
-
Stomach Neoplasms / drug therapy
-
Stomach Neoplasms / genetics*
-
Stomach Neoplasms / microbiology
-
Translocation, Genetic*
Substances
-
API2-MALT1 fusion protein, human
-
Anti-Bacterial Agents
-
Oncogene Proteins, Fusion
-
RNA, Neoplasm