Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs

MeSH terms

• Anti-Inflammatory Agents, Non-Steroidal / adverse effects
• Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
• Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
• Anticarcinogenic Agents / pharmacology
• Anticarcinogenic Agents / therapeutic use
• Aspirin / adverse effects
• Aspirin / pharmacology
• Aspirin / therapeutic use
• Blood Platelets / drug effects
• Blood Platelets / enzymology
• Cardiovascular Diseases / epidemiology
• Celecoxib
• Colorectal Neoplasms / prevention & control
• Cyclooxygenase 1
• Cyclooxygenase 2
• Cyclooxygenase 2 Inhibitors
• Cyclooxygenase Inhibitors / adverse effects
• Cyclooxygenase Inhibitors / pharmacology*
• Cyclooxygenase Inhibitors / therapeutic use
• Depression, Chemical
• Dinoprostone / biosynthesis
• Epoprostenol / biosynthesis
• Gastric Mucosa / drug effects
• Gastrointestinal Hemorrhage / chemically induced
• Gastrointestinal Hemorrhage / epidemiology
• Gastrointestinal Hemorrhage / prevention & control
• Humans
• Incidence
• Intestinal Mucosa / drug effects
• Isoenzymes / antagonists & inhibitors*
• Isoenzymes / physiology
• Lactones / adverse effects
• Lactones / pharmacology
• Lactones / therapeutic use
• Membrane Proteins
• Peptic Ulcer / chemically induced
• Peptic Ulcer / epidemiology
• Peptic Ulcer / prevention & control
• Prostaglandin-Endoperoxide Synthases / physiology
• Prostaglandins / biosynthesis*
• Pyrazoles
• Randomized Controlled Trials as Topic
• Substrate Specificity
• Sulfonamides / adverse effects
• Sulfonamides / pharmacology
• Sulfonamides / therapeutic use
• Sulfones
• Thromboembolism / epidemiology
• Thromboembolism / prevention & control
• Thromboxane A2 / biosynthesis
• Treatment Outcome