IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms

A J Macpherson; L Hunziker; K McCoy; A Lamarre

doi:10.1016/s1286-4579(01)01460-5

IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms

Microbes Infect. 2001 Oct;3(12):1021-35. doi: 10.1016/s1286-4579(01)01460-5.

Authors

A J Macpherson¹, L Hunziker, K McCoy, A Lamarre

Affiliation

¹ Institute of Experimental Immunology, Universitätsspital, Schmelzbergstrasse 12, CH8091, Zürich, Switzerland. amacpher@pathol.unizh.ch

PMID: 11580989
DOI: 10.1016/s1286-4579(01)01460-5

Abstract

IgA is the most abundant immunoglobulin produced in mammals; most is secreted as a dimer across mucous membranes. This review discusses the different mechanisms of induction of IgA, and its role in protecting mucosal surfaces against pathogenic and non-pathogenic microorganisms.

Publication types

Review

MeSH terms

Animals
B-Lymphocytes / physiology
Bile / immunology
Humans
Immunoglobulin A, Secretory / biosynthesis*
Immunoglobulin Class Switching
Intestinal Diseases / immunology
Intestinal Mucosa / immunology*
Intestines / microbiology
Milk / immunology
Rotavirus Infections / immunology

Substances

Immunoglobulin A, Secretory