Abstract
NKT cells are key players in the regulation of antitumor immunity, particularly in experimental models of tumor immunotherapy, such as IL-12 or alpha-galactosylceramide administration. They may also operate in natural antitumor immunity. NKT cells are best known for their immunosuppressive functions; however, NKT cells interact with a range of other cell types (particularly dendritic cells and NK cells) and the outcome of NKT-cell stimulation depends on these and on the cytokine/co-stimulatory milieu.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adjuvants, Immunologic / therapeutic use
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Animals
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Cytotoxicity, Immunologic*
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Dendritic Cells / immunology
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Galactosylceramides / immunology
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Galactosylceramides / therapeutic use
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Humans
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Immunotherapy
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Interferon-gamma / immunology
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Interleukin-12 / immunology
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Interleukin-12 / therapeutic use
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Killer Cells, Natural / immunology*
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Neoplasms / immunology*
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Neoplasms / therapy
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Neoplasms, Experimental / immunology
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Neoplasms, Experimental / therapy
Substances
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Adjuvants, Immunologic
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Galactosylceramides
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Interleukin-12
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Interferon-gamma