Abstract
Apoptosis following loss of cell anchorage is of relevance for development, tissue homeostasis and disease. In the following the role of cell-matrix anchorage as well as cell-cell anchorage for cell survival and apoptosis is reviewed and the complex molecular mechanisms inducing and perpetuating detachment-induced apoptosis will be discussed with special emphasis on the role of caspases, p53, bcl-2 family members and the Fas signaling pathway.
MeSH terms
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Anoikis / physiology*
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Apoptosis / physiology*
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Cadherins / metabolism
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Caspases / metabolism
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Cell Adhesion / physiology
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Cell Survival
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Cell Transformation, Neoplastic
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Homeostasis*
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Models, Biological
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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Signal Transduction / physiology
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Tumor Suppressor Protein p53 / metabolism
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fas Receptor / metabolism
Substances
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Cadherins
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Proto-Oncogene Proteins c-bcl-2
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Tumor Suppressor Protein p53
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fas Receptor
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Caspases