Abstract
Separation of distinct body, organ and tissue compartments, and maintenance of epithelial cell polarity require tight junctions (TJ)-cell-cell junctions located in the apicolateral regions of epithelial and endothelial cells. Studies on the protein components of vertebrate TJ have revealed an intricate network of membrane, sub-membrane, cytoskeletal, and signalling molecules. How these molecules functionally interact to provide TJ with their functions, and what roles these molecules play in control of cell growth and differentiation is a fundamental problem in cell biology.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Caenorhabditis elegans Proteins / metabolism
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Carrier Proteins / metabolism
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Cell Adhesion Molecules / metabolism
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Coxsackie and Adenovirus Receptor-Like Membrane Protein
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Guanylate Kinases
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Intracellular Signaling Peptides and Proteins
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Junctional Adhesion Molecules
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Kinesins / metabolism
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Membrane Proteins / metabolism
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Minor Histocompatibility Antigens
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Myosins / metabolism
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Nucleoside-Phosphate Kinase / metabolism
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PTEN Phosphohydrolase
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Phosphoric Monoester Hydrolases / metabolism
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Protein Kinase C / metabolism
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Protein Serine-Threonine Kinases / metabolism
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Proteins / metabolism
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Receptors, Virus / metabolism
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Tight Junctions / metabolism*
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Transcription Factors / metabolism
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Tumor Suppressor Proteins / metabolism
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WNK Lysine-Deficient Protein Kinase 1
Substances
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Caenorhabditis elegans Proteins
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Carrier Proteins
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Cell Adhesion Molecules
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Clmp protein, rat
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Coxsackie and Adenovirus Receptor-Like Membrane Protein
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Intracellular Signaling Peptides and Proteins
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Junctional Adhesion Molecules
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Membrane Proteins
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Minor Histocompatibility Antigens
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Mpdz protein, rat
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Proteins
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Receptors, Virus
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Transcription Factors
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Tumor Suppressor Proteins
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afd-1 protein, C elegans
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par-6 protein, C elegans
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PAR-3 protein, C elegans
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Protein Serine-Threonine Kinases
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WNK Lysine-Deficient Protein Kinase 1
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Wnk1 protein, rat
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PKC-3 protein
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Protein Kinase C
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Nucleoside-Phosphate Kinase
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Guanylate Kinases
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Phosphoric Monoester Hydrolases
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PTEN Phosphohydrolase
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Myosins
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Kinesins