Abstract
The disease mechanisms of complex inflammatory disorders are difficult to define because of extensive interactions between genetic and environmental factors. Coeliac disease is a typical complex inflammatory disorder, but this disease is unusual in that crucial genetic and environmental factors have been identified. This knowledge has allowed functional studies of the predisposing HLA molecules, the identification of antigenic epitopes and detailed studies of disease-relevant T cells in coeliac disease. This dissection of the pathogenic mechanisms of coeliac disease has uncovered principles that are relevant to other chronic inflammatory diseases.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Autoimmune Diseases / immunology
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CD4-Positive T-Lymphocytes / immunology
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Celiac Disease / genetics
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Celiac Disease / immunology*
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Celiac Disease / pathology
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Epitopes / chemistry
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Epitopes / immunology
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GTP-Binding Proteins / analysis
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Genetic Predisposition to Disease
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Glutens / immunology
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Glutens / metabolism
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HLA-DQ Antigens / genetics
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HLA-DQ Antigens / immunology*
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Humans
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Inflammation / immunology*
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Interferon-gamma / analysis
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Intestinal Mucosa / immunology
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Intestinal Mucosa / pathology
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Intestine, Small / enzymology
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Intestine, Small / immunology
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Intestine, Small / pathology
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Molecular Sequence Data
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Protein Glutamine gamma Glutamyltransferase 2
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Transglutaminases / analysis
Substances
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Epitopes
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HLA-DQ Antigens
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Glutens
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Interferon-gamma
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Protein Glutamine gamma Glutamyltransferase 2
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Transglutaminases
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GTP-Binding Proteins