[Expression of tissue factor and vascular endothelial growth factor in colorectal carcinoma]

Tumori. 2003 Jul-Aug;89(4 Suppl):5-6.
[Article in Italian]

Abstract

Tissue factor (TF) and vascular endothelial growth factor (VEGF) play an important role in tumor progression and metastasis. We analyzed their expression in the carcinoma and normal mucosa of 53 colorectal cancer patients. VEGF levels were significantly higher in the tumor and correlated with TF expression. No correlation was found with tumor stage. TF may influence tumor growth and metastasis by modulating VEGF expression and neoangiogenesis.

Publication types

  • English Abstract

MeSH terms

  • Adenocarcinoma / genetics
  • Adenocarcinoma / metabolism*
  • Adenocarcinoma / pathology
  • Colorectal Neoplasms / genetics
  • Colorectal Neoplasms / metabolism*
  • Colorectal Neoplasms / pathology
  • Endothelial Growth Factors / biosynthesis*
  • Endothelial Growth Factors / genetics
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Intercellular Signaling Peptides and Proteins / biosynthesis*
  • Intercellular Signaling Peptides and Proteins / genetics
  • Intestinal Mucosa / metabolism
  • Lymphokines / biosynthesis*
  • Lymphokines / genetics
  • Neoplasm Proteins / biosynthesis*
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / physiology
  • Neoplasm Staging
  • Neovascularization, Pathologic / genetics
  • Neovascularization, Pathologic / metabolism
  • Thromboplastin / biosynthesis*
  • Thromboplastin / genetics
  • Thromboplastin / physiology
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • Endothelial Growth Factors
  • Intercellular Signaling Peptides and Proteins
  • Lymphokines
  • Neoplasm Proteins
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • Thromboplastin