Abstract
Stat3 is a vital transcription factor that is activated downstream of the gp130 receptor, primarily via IL-6 signaling in adult liver. A new study demonstrates that Stat3 provides hepatoprotection against Fas-mediated apoptotic liver damage by two mechanisms: direct inactivation of caspases and reduction of reactive oxygen species.
MeSH terms
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Animals
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Apoptosis*
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Cell Survival
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Cytoprotection*
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DNA-Binding Proteins / physiology*
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Interleukin-6 / physiology*
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Liver / pathology*
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Liver Regeneration
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Mice
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Oxidation-Reduction
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STAT3 Transcription Factor
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Signal Transduction
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Trans-Activators / physiology*
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fas Receptor / physiology*
Substances
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DNA-Binding Proteins
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Interleukin-6
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STAT3 Transcription Factor
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Stat3 protein, mouse
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Trans-Activators
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fas Receptor