Involvement of N-methyl-d-aspartate (NMDA) receptors in a rat model of visceral hypersensitivity

Geneviève-Anne Gaudreau; Victor Plourde

doi:10.1016/j.bbr.2003.07.004

Involvement of N-methyl-d-aspartate (NMDA) receptors in a rat model of visceral hypersensitivity

Behav Brain Res. 2004 Apr 2;150(1-2):185-9. doi: 10.1016/j.bbr.2003.07.004.

Authors

Geneviève-Anne Gaudreau¹, Victor Plourde

Affiliation

¹ Neurobiology and Digestive Motility Laboratory, Hopital St-Luc, CHUM Research Center, University of Montreal, 264 East René-Lévesque, Montréal, Que., Canada H2X 1P1.

PMID: 15033291
DOI: 10.1016/j.bbr.2003.07.004

Abstract

N-Methyl-d-aspartate (NMDA) is known to be involved in the transmission of nociceptive information. In the present study, we investigated the effect of peripheral and central NMDA receptor antagonist MK-801 in visceral hypersensitivity. In an animal model of colorectal distension (CRD), administration of both intrathecal MK-801 (1.5 nmol) and intraperitoneal MK-801 (0.15 mg/kg) completely abolished the CRD-induced visceral hypersensitivity of noxious and innocuous stimuli. Thus, the results from this experiment demonstrate the efficacy of MK-801 in blocking the visceral hypersensitivity mediated by central and peripheral mechanisms.

MeSH terms

Abdomen / physiology
Animals
Behavior, Animal / drug effects
Colon / physiology
Disease Models, Animal
Dizocilpine Maleate / administration & dosage
Dizocilpine Maleate / pharmacology*
Excitatory Amino Acid Antagonists / administration & dosage
Excitatory Amino Acid Antagonists / pharmacology*
Hyperalgesia / physiopathology*
Injections, Intraperitoneal
Injections, Spinal
Male
Muscle Contraction / physiology
Physical Stimulation
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate / drug effects
Receptors, N-Methyl-D-Aspartate / physiology*
Rectum / physiology

Substances

Excitatory Amino Acid Antagonists
Receptors, N-Methyl-D-Aspartate
Dizocilpine Maleate