TFF3 expression at the esophagogastric junction is increased in gastro-esophageal reflux disease (GERD)

Ulrich Peitz; Irina Kouznetsova; Thomas Wex; Ingrid Gebert; Michael Vieth; Albert Roessner; Werner Hoffmann; Peter Malfertheiner

doi:10.1016/j.peptides.2004.01.018

TFF3 expression at the esophagogastric junction is increased in gastro-esophageal reflux disease (GERD)

Peptides. 2004 May;25(5):771-7. doi: 10.1016/j.peptides.2004.01.018.

Authors

Ulrich Peitz¹, Irina Kouznetsova, Thomas Wex, Ingrid Gebert, Michael Vieth, Albert Roessner, Werner Hoffmann, Peter Malfertheiner

Affiliation

¹ Department of Gastroenterology, Hepatology, and Infectiology, Otto-von-Guericke University, Leipziger Str. 44, D-39120 Magdeburg, Germany. ulrich.peitz@medizin.uni-magdeburg.de

PMID: 15177871
DOI: 10.1016/j.peptides.2004.01.018

Abstract

At the gastric cardia, the molecular mechanisms of inflammation and metaplasia are incompletely understood. Thus, the aim of this study was to determine the expression of TFF1, TFF2 and TFF3 at this site and correlate these data with Helicobacter pylori infection or gastro-esophageal reflux disease (GERD). In 27 patients without intestinal metaplasia at the cardia, endoscopic biopsies were obtained for histology and RT-PCR. TFF1 and TFF2 were expressed in all cardia samples. TFF3 expression was significantly more frequent at the cardia (n = 15/24) than in the corpus (n = 2/26). TFF3 expression at the cardia was mainly observed in GERD patients, and there was a clear tendency towards higher interleukin-8 (IL-8) transcription levels; whereas TFF3 expression was not correlated with the H. pylori status or to tumor necrosis factor-alpha (TNF-alpha) expression. The expression of TFF3 at the cardia may represent an adaptation to GERD and precede the development of Barrett's esophagus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Barrett Esophagus / metabolism
Barrett Esophagus / microbiology
Barrett Esophagus / pathology
Cardia / metabolism
Cardia / microbiology
Cardia / pathology
Esophagogastric Junction / metabolism*
Esophagogastric Junction / microbiology
Esophagogastric Junction / pathology
Gastroesophageal Reflux / metabolism*
Gastroesophageal Reflux / microbiology
Gastroesophageal Reflux / pathology
Helicobacter Infections / metabolism
Helicobacter Infections / pathology
Helicobacter pylori / metabolism
Humans
Interleukin-8 / metabolism
Mucins / metabolism*
Muscle Proteins / metabolism*
Peptides / metabolism*
Proteins / metabolism*
Trefoil Factor-1
Trefoil Factor-2
Trefoil Factor-3
Tumor Necrosis Factor-alpha / metabolism
Tumor Suppressor Proteins

Substances

Interleukin-8
Mucins
Muscle Proteins
Peptides
Proteins
TFF1 protein, human
TFF2 protein, human
TFF3 protein, human
TNF protein, human
Trefoil Factor-1
Trefoil Factor-2
Trefoil Factor-3
Tumor Necrosis Factor-alpha
Tumor Suppressor Proteins