Abstract
Molecular scaffold or adaptor proteins facilitate precise spatiotemporal regulation and integration of multiple signaling pathways to effect the optimal cellular response to changes in the immediate environment. Paxillin is a multidomain adaptor that recruits both structural and signaling molecules to focal adhesions, sites of integrin engagement with the extracellular matrix, where it performs a critical role in transducing adhesion and growth factor signals to elicit changes in cell migration and gene expression.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Adhesion / physiology
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Cell Division / physiology
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Cell Movement / physiology
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Cytoskeletal Proteins / chemistry*
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Cytoskeletal Proteins / physiology*
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Extracellular Matrix / physiology
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Growth Substances / physiology
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Humans
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Integrins / physiology
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Paxillin
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Phosphoproteins / chemistry*
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Phosphoproteins / physiology*
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Signal Transduction / physiology*
Substances
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Cytoskeletal Proteins
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Growth Substances
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Integrins
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PXN protein, human
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Paxillin
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Phosphoproteins