Abstract
The purposes of this study were to determine plasma and intestinal epinephrine (E) and norepinephrine (NE) concentrations in mice after exercise stress and, the effect of intravenous injection of E and NE (at concentrations during exercise) on viability of intestinal lymphocytes (IL). Exhaustive exercise significantly elevated plasma E and NE, and intestinal E, compared with sedentary animals. Twenty-four hours after intravenous NE administration, IL counts were higher (p<0.001) and % apoptotic IL were lower (p<0.001) than saline conditions. E resulted in fewer apoptotic IL at 24 h compared to saline controls. E and NE differentially influence IL numbers at 24 h after injection although both result in fewer % apoptotic IL relative to mice given saline only.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Annexin A5 / metabolism
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Apoptosis / drug effects*
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Blotting, Western / methods
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Cell Count / methods
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Chromatography, High Pressure Liquid / methods
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Electrochemistry / methods
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Epinephrine / blood
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Epinephrine / toxicity*
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Female
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Flow Cytometry / methods
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Gene Expression Regulation / drug effects
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Injections, Intravenous / methods
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Intestines / cytology*
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Leukocyte Common Antigens / metabolism
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Lymphocytes / cytology
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Lymphocytes / drug effects*
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Mice
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Mice, Inbred C57BL
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Norepinephrine / blood
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Norepinephrine / toxicity*
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Phenotype
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Physical Conditioning, Animal / methods
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Propidium
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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Random Allocation
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Tissue Distribution
Substances
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Annexin A5
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Proto-Oncogene Proteins c-bcl-2
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Propidium
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Leukocyte Common Antigens
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Norepinephrine
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Epinephrine