Abstract
There is a spectrum of distinct disease states that have in common their effect of breaking down epithelial and/or endothelial barrier function. Fluid compartmentalization goes awry, with profound implications for epithelial and stromal homeostasis, fluid and/or electrolyte balance, generation of inflammatory states, and even tumor microenvironment. Specific effects on the tight junction are found to be integral to bacterial invasion and tumor progression.
MeSH terms
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Animals
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Bacterial Infections / pathology
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Bacterial Infections / physiopathology
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Diabetes Mellitus / pathology
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Diabetes Mellitus / physiopathology
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Endothelium / physiopathology*
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Endothelium / ultrastructure
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Epithelium / physiopathology*
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Epithelium / ultrastructure
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Genetic Diseases, Inborn / genetics
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Homeostasis
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Humans
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Inflammation / immunology
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Neoplasms / pathology
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Neoplasms / physiopathology
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Tight Junctions / physiology
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Virus Diseases / pathology
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Virus Diseases / physiopathology