Abstract
Methylated catechols like apocynin selectively inhibits neutrophil superoxide production without significant side-effects. When rats were treated orally with low doses of apocynin the severity of collagen-induced arthritis was significantly reduced, pointing at a role of oxyradicals in the induction of this disease.
MeSH terms
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Acetophenones / pharmacology*
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Arthritis, Experimental / drug therapy*
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Collagen
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Enzyme-Linked Immunosorbent Assay
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Free Radicals
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Immunoglobulin G / biosynthesis
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In Vitro Techniques
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Male
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Neutrophils / drug effects
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Neutrophils / metabolism*
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Oxidation-Reduction
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Rats
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Rats, Inbred Strains
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Superoxides / metabolism
Substances
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Acetophenones
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Anti-Inflammatory Agents, Non-Steroidal
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Free Radicals
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Immunoglobulin G
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Superoxides
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Collagen
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acetovanillone