Abstract
Aim:
To compare the one-day quadruple therapy with a standard 7-d triple therapy for H pylori eradication in a rural population of China.
Methods:
A total of 396 patients with (13)C-urea breath test positive for H pylori were assigned into two groups: 239 patients received one-day quadruple therapy (amoxicillin 2000 mg qid; metronidazole 500 mg qid; bismuth citrate 900 mg qid and lansoprazole 60 mg once daily) and 157 patients received 7-d standard triple therapy (amoxicillin 1000 mg bid; clarithromycin 500 mg bid and lansoprazole 30 mg bid). All the patients underwent a (13)C-UBT to assess the eradication of H pylori infection six weeks after treatment.
Results:
Two hundred and twenty-nine patients completed the one-day therapy (95.8%) and 148 patients completed the 7-d therapy (94.2%). The one-day therapy eradicated H pylori infection in 64 patients (27.95%). In contrast, 103 patients (69.59%) were H pylori negative after the 7-d therapy (P < 0.01).
Conclusion:
This pilot study suggests there is no beneficial effect of the one-day therapy in treatment of H pylori infection compared with the 7-d standard therapy.
Publication types
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Comparative Study
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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2-Pyridinylmethylsulfinylbenzimidazoles
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Adult
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Amoxicillin / administration & dosage
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Amoxicillin / pharmacology
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Amoxicillin / therapeutic use
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / pharmacology
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Anti-Infective Agents / therapeutic use*
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Clarithromycin / administration & dosage
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Clarithromycin / pharmacology
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Clarithromycin / therapeutic use
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Drug Therapy, Combination
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Female
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Helicobacter Infections / drug therapy*
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Helicobacter pylori / drug effects
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Helicobacter pylori / pathogenicity*
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Humans
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Lansoprazole
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Male
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Metronidazole / administration & dosage
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Metronidazole / pharmacology
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Metronidazole / therapeutic use
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Middle Aged
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Omeprazole / administration & dosage
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Omeprazole / analogs & derivatives
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Omeprazole / pharmacology
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Omeprazole / therapeutic use
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Organometallic Compounds / administration & dosage
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Organometallic Compounds / pharmacology
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Organometallic Compounds / therapeutic use
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Pilot Projects
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Prospective Studies
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Rural Population*
Substances
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2-Pyridinylmethylsulfinylbenzimidazoles
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Anti-Bacterial Agents
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Anti-Infective Agents
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Organometallic Compounds
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Lansoprazole
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Metronidazole
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Amoxicillin
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Clarithromycin
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bismuth tripotassium dicitrate
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Omeprazole