p53 aerobics: the major tumor suppressor fuels your workout

Jan-Philipp Kruse; Wei Gu

doi:10.1016/j.cmet.2006.06.004

p53 aerobics: the major tumor suppressor fuels your workout

Cell Metab. 2006 Jul;4(1):1-3. doi: 10.1016/j.cmet.2006.06.004.

Authors

Jan-Philipp Kruse¹, Wei Gu

Affiliation

¹ Institute for Cancer Genetics, and Department of Pathology, College of Physicians & Surgeons, Columbia University, 1150 St. Nicholas Ave, New York, New York 10032, USA.

PMID: 16814724
DOI: 10.1016/j.cmet.2006.06.004

Abstract

In addition to its role as the central regulator of the cellular stress response, p53 can regulate aerobic respiration via the novel transcriptional target SCO2, a critical regulator of the cytochrome c oxidase complex (Matoba et al., 2006). Loss of p53 results in decreased oxygen consumption and aerobic respiration and promotes a switch to glycolysis, thereby reducing endurance during physical exercise.

Publication types

Review

MeSH terms

Aerobiosis
Animals
Carrier Proteins
Electron Transport Complex IV / genetics
Electron Transport Complex IV / metabolism
Energy Metabolism / genetics
Energy Metabolism / physiology*
Glycolysis
Humans
Mitochondrial Proteins
Molecular Chaperones
Oxygen Consumption / physiology
Proteins / genetics
Proteins / metabolism
Transcription, Genetic
Tumor Suppressor Protein p53 / deficiency
Tumor Suppressor Protein p53 / metabolism*

Substances

Carrier Proteins
Mitochondrial Proteins
Molecular Chaperones
Proteins
SCO2 protein, human
SCO2 protein, mouse
Tumor Suppressor Protein p53
Electron Transport Complex IV