Long-term aspirin use and colorectal cancer risk: a cohort study in Sweden

Br J Cancer. 2006 Nov 6;95(9):1277-9. doi: 10.1038/sj.bjc.6603442. Epub 2006 Oct 24.

Abstract

In a prospective cohort study of 74 250 Swedish women and men, with 7.2 years of follow-up and 705 incident colorectal cancer cases, long duration of aspirin use (>20 years) was associated with a reduced risk of colorectal cancer (multivariate rate ratio: 0.65; 95% confidence interval: 0.45-0.94). Aspirin use for a shorter period was not associated with risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Aspirin / administration & dosage*
  • Body Mass Index
  • Cohort Studies
  • Colorectal Neoplasms / epidemiology
  • Colorectal Neoplasms / genetics
  • Colorectal Neoplasms / prevention & control*
  • Educational Status
  • Family Health
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Prospective Studies
  • Risk Factors
  • Surveys and Questionnaires
  • Sweden / epidemiology
  • Time Factors

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Aspirin