Abstract
Considerable progress has been made in improving disease-free survival in stage III colon cancer with the use of adjuvant chemotherapy. In recent years, it has been shown that infusional 5-fluorouracil regimens maintain the efficacy and reduce toxicity associated with bolus 5-fluorouracil, that improved tolerability can be achieved with use of the oral fluoropyrimidine capecitabine, and that improved efficacy can be achieved by combining 5-fluorouracil/leucovorin with other cytotoxic agents (eg, oxaliplatin and irinotecan). Studies are ongoing to identify optimal adjuvant regimens in stage II or III disease and to identify the potential benefits of adding bevacizumab or cetuximab to adjuvant therapy.
MeSH terms
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Antibodies, Monoclonal / administration & dosage
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Antimetabolites, Antineoplastic / administration & dosage
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Camptothecin / administration & dosage
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Camptothecin / analogs & derivatives
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Capecitabine
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Colonic Neoplasms / drug therapy*
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Colonic Neoplasms / pathology
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Deoxycytidine / administration & dosage
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Deoxycytidine / analogs & derivatives
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Disease-Free Survival
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Fluorouracil / administration & dosage
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Fluorouracil / analogs & derivatives
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Humans
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Irinotecan
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Leucovorin / administration & dosage
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Neoplasm Staging
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Organoplatinum Compounds / administration & dosage
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Oxaliplatin
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Prodrugs / administration & dosage
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Rectal Neoplasms / drug therapy*
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Rectal Neoplasms / pathology
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Vitamin B Complex / administration & dosage
Substances
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Antibodies, Monoclonal
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Antimetabolites, Antineoplastic
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Antineoplastic Agents
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Antineoplastic Agents, Phytogenic
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Organoplatinum Compounds
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Prodrugs
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Oxaliplatin
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Deoxycytidine
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Vitamin B Complex
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Capecitabine
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Irinotecan
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Leucovorin
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Fluorouracil
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Camptothecin