Effect of erythroid differentiation factor on megakaryocytic differentiation of L8057, a murine megakaryoblastic leukemia cell line

Biochem Biophys Res Commun. 1991 Dec 31;181(3):1042-7. doi: 10.1016/0006-291x(91)92042-i.

Abstract

To assess the potent effect of erythroid differentiation factor (EDF) on megakaryocytopoiesis, effect of EDF on megakaryocytic differentiation of L8057, a murine megakaryoblastic cell line, was examined. EDF potentiated AchE induction of L8057 in a dose dependent manner. The potency of EDF on megakaryocytic differentiation is comparable to that on erythroid differentiation reported previously. The present results suggest that EDF may play a regulatory role in megakaryocytopoiesis as well as in erythropoiesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / metabolism
  • Activins
  • Animals
  • Cell Differentiation / drug effects*
  • Cell Line
  • Dose-Response Relationship, Drug
  • Inhibins / pharmacology*
  • Kinetics
  • Leukemia, Experimental
  • Megakaryocytes / cytology*
  • Megakaryocytes / drug effects
  • Mice
  • Tetradecanoylphorbol Acetate / pharmacology

Substances

  • Activins
  • Inhibins
  • Acetylcholinesterase
  • Tetradecanoylphorbol Acetate