Abstract
Triggering receptor expressed on myeloid cells (TREM) proteins play important roles in innate and adaptive immunity. Since the discovery of TREM-1 and TREM-2 in 2000, the field has exploded over the past 8 years and currently TREM-1 is thought of as an amplifier of the immune response, while TREM-2 is believed to be a negative regulator. Here, we discuss the current state of the literature on TREMs, with a focus on TREM-1 and TREM-2 and their expression, signaling in mononuclear phagocytes and roles in innate immunity and bacterial infection.
MeSH terms
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Animals
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Bacterial Infections / genetics
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Bacterial Infections / immunology*
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Cytokines / immunology
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Cytokines / metabolism
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Humans
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Immunity, Innate*
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Inflammation / genetics
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Inflammation / immunology*
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / physiology*
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Multigene Family
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Receptors, Immunologic / genetics
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Receptors, Immunologic / physiology*
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Signal Transduction
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Triggering Receptor Expressed on Myeloid Cells-1
Substances
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Cytokines
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Membrane Glycoproteins
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Receptors, Immunologic
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TREM1 protein, human
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TREM2 protein, human
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Triggering Receptor Expressed on Myeloid Cells-1