From expression to signaling: roles of TREM-1 and TREM-2 in innate immunity and bacterial infection

Immunobiology. 2008;213(9-10):701-13. doi: 10.1016/j.imbio.2008.07.008. Epub 2008 Sep 7.

Abstract

Triggering receptor expressed on myeloid cells (TREM) proteins play important roles in innate and adaptive immunity. Since the discovery of TREM-1 and TREM-2 in 2000, the field has exploded over the past 8 years and currently TREM-1 is thought of as an amplifier of the immune response, while TREM-2 is believed to be a negative regulator. Here, we discuss the current state of the literature on TREMs, with a focus on TREM-1 and TREM-2 and their expression, signaling in mononuclear phagocytes and roles in innate immunity and bacterial infection.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacterial Infections / genetics
  • Bacterial Infections / immunology*
  • Cytokines / immunology
  • Cytokines / metabolism
  • Humans
  • Immunity, Innate*
  • Inflammation / genetics
  • Inflammation / immunology*
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / physiology*
  • Multigene Family
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / physiology*
  • Signal Transduction
  • Triggering Receptor Expressed on Myeloid Cells-1

Substances

  • Cytokines
  • Membrane Glycoproteins
  • Receptors, Immunologic
  • TREM1 protein, human
  • TREM2 protein, human
  • Triggering Receptor Expressed on Myeloid Cells-1