Autophagy gives a nod and a wink to the inflammasome and Paneth cells in Crohn's disease

Vojo Deretic; Sharon Master; Sudha Singh

doi:10.1016/j.devcel.2008.10.009

Autophagy gives a nod and a wink to the inflammasome and Paneth cells in Crohn's disease

Dev Cell. 2008 Nov;15(5):641-2. doi: 10.1016/j.devcel.2008.10.009.

Authors

Vojo Deretic¹, Sharon Master, Sudha Singh

Affiliation

¹ Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, The University of New Mexico, Northeast Albuquerque, NM 87131, USA. vderetic@salud.unm.edu

Abstract

Recent genome-wide association studies have linked polymorphisms in two atophagy genes, Atg16L1 and IRGM, with Crohn's Disease. Now, experiments with Atg16L1 transgenic mice indicate multiple roles for autophagy in inflammatory bowel disease via effects on Paneth cells, a runaway inflammasome, and the proinflammatory cytokine IL-1beta.

MeSH terms

Animals
Autophagy*
Autophagy-Related Proteins
Carrier Proteins / genetics
Carrier Proteins / immunology
Crohn Disease / genetics
Crohn Disease / immunology*
GTP-Binding Proteins / genetics
Humans
Mice
Mice, Transgenic
Nod2 Signaling Adaptor Protein / immunology*
Paneth Cells / immunology*

Substances

Atg16l1 protein, mouse
Autophagy-Related Proteins
Carrier Proteins
Ifi1 protein, mouse
Nod2 Signaling Adaptor Protein
GTP-Binding Proteins

Abstract

MeSH terms

Substances

Grants and funding