Abstract
Toll-like receptors (TLRs) are a family of pattern recognition receptors that are best-known for their role in host defence from infection. Emerging evidence also suggests that TLRs have an important role in maintaining tissue homeostasis by regulating the inflammatory and tissue repair responses to injury. The development of cancer has been associated with microbial infection, injury, inflammation and tissue repair. Here we discuss how the function of TLRs may relate to these processes in the context of carcinogenesis.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Transformation, Neoplastic*
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Homeostasis
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Humans
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Immunologic Surveillance
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Immunotherapy, Adoptive
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Infections / immunology
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Infections / physiopathology
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Inflammation / immunology
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Inflammation / physiopathology
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Ligands
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Mice
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Myeloid Differentiation Factor 88 / deficiency
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Myeloid Differentiation Factor 88 / physiology
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Neoplasm Proteins / physiology*
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Neoplasms / immunology
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Neoplasms / metabolism*
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Neoplasms / therapy
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Regeneration / physiology
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Signal Transduction / physiology
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T-Lymphocyte Subsets / immunology
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Toll-Like Receptors / physiology*
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Wound Healing / physiology
Substances
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Ligands
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Myd88 protein, mouse
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Myeloid Differentiation Factor 88
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Neoplasm Proteins
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Toll-Like Receptors