Abstract
Epithelial-mesenchymal transitions (EMTs) are believed to play a role in invasion and metastasis of many types of tumors. In this issue of the JCI, Chen et al. show that a gene that has been associated with aggressive biology in hepatocellular carcinomas initiates a molecular cascade that results in EMT.
Publication types
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Comment
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Carcinoma, Hepatocellular / etiology*
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Carcinoma, Hepatocellular / pathology
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Cell Differentiation
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DNA Helicases / genetics
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DNA Helicases / physiology
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / physiology
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Epithelial Cells / pathology*
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Humans
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Liver Cirrhosis / complications
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Liver Neoplasms / etiology*
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Liver Neoplasms / pathology
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Mesoderm / pathology*
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Mice
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cdc42 GTP-Binding Protein / physiology
Substances
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DNA-Binding Proteins
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DNA Helicases
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CHD1L protein, human
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cdc42 GTP-Binding Protein