TGF-Beta to the rescue

Ethan M Shevach

doi:10.1016/j.immuni.2010.04.014

TGF-Beta to the rescue

Immunity. 2010 May 28;32(5):585-7. doi: 10.1016/j.immuni.2010.04.014.

Author

Ethan M Shevach¹

Affiliation

¹ Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. eshevach@niaid.nih.gov

PMID: 20510867
DOI: 10.1016/j.immuni.2010.04.014

Abstract

Is transforming growth factor-beta (TGF-beta) required for induction of the transcription factor Foxp3 in developing thymocytes? Ouyang et al. (2010) demonstrate that TGF-beta in the thymus prevents deletion of Foxp3(+) regulatory T cells.

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