Disseminated and circulating tumor cells in gastrointestinal oncology

F C Bidard; F R Ferrand; F Huguet; P Hammel; C Louvet; D Malka; V Boige; M Ducreux; T Andre; A de Gramont; P Mariani; J Y Pierga

doi:10.1016/j.critrevonc.2011.05.008

Disseminated and circulating tumor cells in gastrointestinal oncology

Crit Rev Oncol Hematol. 2012 May;82(2):103-15. doi: 10.1016/j.critrevonc.2011.05.008. Epub 2011 Jun 15.

Authors

F C Bidard¹, F R Ferrand, F Huguet, P Hammel, C Louvet, D Malka, V Boige, M Ducreux, T Andre, A de Gramont, P Mariani, J Y Pierga

Affiliation

¹ Department of Medical Oncology, Institut Curie, Paris, France. fcbidard@curie.fr

PMID: 21680197
DOI: 10.1016/j.critrevonc.2011.05.008

Abstract

Circulating (CTCs) and disseminated tumor cells (DTCs) are two different steps in the metastatic process. Several recent techniques have allowed detection of these cells in patients, and have generated many results using different isolation techniques in small cohorts. Herein, we review the detection results and their clinical consequence in esophageal, gastric, pancreatic, colorectal, and liver carcinomas, and discuss their possible applications as new biomarkers.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Gastrointestinal Neoplasms / blood
Gastrointestinal Neoplasms / pathology*
Gastrointestinal Neoplasms / therapy
Humans
Neoplastic Cells, Circulating*