Abstract
Bcl-3 is an established oncogene in hematologic malignancies, such as B-cell chronic lymphocytic leukemias. Nevertheless, recent research has shown that it also participates in progression of diverse solid tumors. The present review summarizes the current knowledge of Bcl3 role in solid tumors progression, including some new insights in its possible molecular mechanisms of action.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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B-Cell Lymphoma 3 Protein
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B-Lymphocytes / pathology
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Cell Proliferation
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Humans
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Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*
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Leukemia, Lymphocytic, Chronic, B-Cell / pathology
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins / metabolism*
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Transcription Factors / genetics
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Transcription Factors / metabolism*
Substances
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B-Cell Lymphoma 3 Protein
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BCL3 protein, human
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Proto-Oncogene Proteins
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Transcription Factors