As to the prevention of somatic and psychosomatic diseases it should be tested, whether life-events are of interest to pathogenesis of disturbances like multiple sclerosis and ulcerative colitis. The social readjustment rating scale (Holmes, Rahe) was used and the life-change-unite-score of the groups of patients (n = 30) and a normal population was compared. Patients with m.s. and u.c. have a significant higher LCU-score than the normal group. Between the two diseases one can find no difference.