B regulatory cells in cancer

Frances Balkwill; Anne Montfort; Melania Capasso

doi:10.1016/j.it.2012.10.007

B regulatory cells in cancer

Trends Immunol. 2013 Apr;34(4):169-73. doi: 10.1016/j.it.2012.10.007. Epub 2012 Dec 1.

Authors

Frances Balkwill¹, Anne Montfort, Melania Capasso

Affiliation

¹ Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK. f.balkwill@qmul.ac.uk

PMID: 23206438
DOI: 10.1016/j.it.2012.10.007

Abstract

B regulatory cells are a newly described subpopulation of B cells that appear to play important roles in autoimmunity and more recently, in cancer. In this review we summarize our current knowledge of B regulatory cells, as well as the body of evidence pointing towards a role for B cells in general, and B regulatory cells in particular, in promoting tumor growth.

Publication types

Review

MeSH terms

Animals
Autoimmunity
B-Lymphocyte Subsets / immunology*
B-Lymphocytes, Regulatory / immunology*
Carcinogenesis
Humans
Immunomodulation
Neoplasms / immunology*