Abstract
A potential adverse effect of dipeptidyl peptidase-4 inhibitors (DPP-4i) on the pancreas remains controversial. We evaluated the DPP-4i effects on pancreatic amylase and lipase activity in patients with type 2 diabetes. These enzymes were slightly but significantly increased, suggesting DPP-4i cause a low-grade inflammatory change in the exocrine pancreas.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
MeSH terms
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Aged
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Diabetes Mellitus, Type 2 / blood
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Diabetes Mellitus, Type 2 / drug therapy
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Diabetes Mellitus, Type 2 / enzymology*
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Dipeptidyl-Peptidase IV Inhibitors / therapeutic use*
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Female
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Humans
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Lipase / blood
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Male
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Middle Aged
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Pancreas / drug effects
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Pancreas / enzymology
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Pancreatic alpha-Amylases / blood
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Pancreatitis / blood
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Retrospective Studies
Substances
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Dipeptidyl-Peptidase IV Inhibitors
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Lipase
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Pancreatic alpha-Amylases