A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Nat Cell Biol. 2013 Aug;15(8):978-90. doi: 10.1038/ncb2784. Epub 2013 Jun 16.

Abstract

Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells implement a complex pro-inflammatory response termed the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence, activates immune surveillance and paradoxically also has pro-tumorigenic properties. Here, we present evidence that the SASP can also induce paracrine senescence in normal cells both in culture and in human and mouse models of OIS in vivo. Coupling quantitative proteomics with small-molecule screens, we identified multiple SASP components mediating paracrine senescence, including TGF-β family ligands, VEGF, CCL2 and CCL20. Amongst them, TGF-β ligands play a major role by regulating p15(INK4b) and p21(CIP1). Expression of the SASP is controlled by inflammasome-mediated IL-1 signalling. The inflammasome and IL-1 signalling are activated in senescent cells and IL-1α expression can reproduce SASP activation, resulting in senescence. Our results demonstrate that the SASP can cause paracrine senescence and impact on tumour suppression and senescence in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cellular Senescence / physiology*
  • Colonic Neoplasms / physiopathology
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Immunohistochemistry
  • Inflammasomes / metabolism*
  • Interleukin-1 / metabolism
  • Mice
  • Models, Animal
  • Paracrine Communication / physiology
  • Protein Binding
  • Signal Transduction
  • Transforming Growth Factor beta1 / metabolism

Substances

  • Inflammasomes
  • Interleukin-1
  • Transforming Growth Factor beta1