The role of diet in triggering human inflammatory disorders in the modern age

Edmond Y Huang; Suzanne Devkota; Dagmara Moscoso; Eugene B Chang; Vanessa A Leone

doi:10.1016/j.micinf.2013.07.004

The role of diet in triggering human inflammatory disorders in the modern age

Microbes Infect. 2013 Nov;15(12):765-74. doi: 10.1016/j.micinf.2013.07.004. Epub 2013 Jul 20.

Authors

Edmond Y Huang¹, Suzanne Devkota, Dagmara Moscoso, Eugene B Chang, Vanessa A Leone

Affiliation

¹ Department of Medicine, University of Chicago, 900 East 57th Street, Chicago, IL 60637, USA. Electronic address: eyhuang@uchicago.edu.

PMID: 23876436
DOI: 10.1016/j.micinf.2013.07.004

Abstract

Previously uncommon human inflammatory disorders are emerging with alarming frequency, possibly triggered by environmental factors introduced through Westernization. This review highlights how Western diets heighten the inflammatory state promoting development of disease. Evidence that this can occur directly or indirectly through perturbations of host-microbe interactions are reviewed.

Keywords: Gut microbiota; High-fat; Immunity; Inflammatory disease; Systemic inflammation; Western diet.

Publication types

Review

MeSH terms

Arthritis, Rheumatoid / epidemiology*
Diet / adverse effects*
Host-Pathogen Interactions*
Humans
Immunity*
Inflammatory Bowel Diseases / epidemiology*
Metabolic Syndrome / epidemiology*