Mechanisms of drug-induced liver injury

Liyun Yuan; Neil Kaplowitz

doi:10.1016/j.cld.2013.07.002

Mechanisms of drug-induced liver injury

Clin Liver Dis. 2013 Nov;17(4):507-18, vii. doi: 10.1016/j.cld.2013.07.002. Epub 2013 Aug 1.

Authors

Liyun Yuan¹, Neil Kaplowitz

Affiliation

¹ USC Research Center for Liver Disease, Department of Medicine, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue (HMR101), Los Angeles, CA 90033, USA.

Abstract

Drug-induced liver injury (DILI) represents a broad spectrum of liver manifestations. However, the most common manifestation is hepatocyte death following drug intake. DILI can be predictable and dose dependent with a notable example of acetaminophen toxicity. Idiosyncratic DILI occurs in an unpredictable fashion at low frequencies, implying that environmental and genetic factors alter the susceptibility of individuals to the insult (drugs).

Keywords: Adaptive immunity; Cell death; HLA associations; Idiosyncratic drug-induced liver injury; Mitochondria; Oxidative stress; Reactive metabolites; Stress signaling.

Mechanisms of drug-induced liver injury

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Affiliation

Abstract

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