Pancreatic cancer stroma: friend or foe?

Jesse Gore; Murray Korc

doi:10.1016/j.ccr.2014.05.026

Pancreatic cancer stroma: friend or foe?

Cancer Cell. 2014 Jun 16;25(6):711-2. doi: 10.1016/j.ccr.2014.05.026.

Authors

Jesse Gore¹, Murray Korc²

Affiliations

¹ Departments of Medicine and Biochemistry and Molecular Biology, Indiana University School of Medicine, Melvin and Bren Simon Cancer Center and Pancreatic Cancer Signature Center, Indianapolis, IN 46202, USA.
² Departments of Medicine and Biochemistry and Molecular Biology, Indiana University School of Medicine, Melvin and Bren Simon Cancer Center and Pancreatic Cancer Signature Center, Indianapolis, IN 46202, USA. Electronic address: mkorc@iu.edu.

Abstract

Pancreatic cancer desmoplasia is thought to confer biological aggressiveness. In this issue of Cancer Cell, Özdemir and colleagues and Rhim and colleagues demonstrate that targeting the stroma results in undifferentiated, aggressive pancreatic cancer that responds to checkpoint blockade or antiangiogenic therapy, uncovering a protective role by stroma in this cancer.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Carcinoma, Pancreatic Ductal / pathology*
Humans
Pancreatic Neoplasms / pathology*
Stromal Cells / pathology*

Abstract

Publication types

MeSH terms

Grants and funding