SnapShot: FMRP mRNA targets and diseases

Emanuela Pasciuto; Claudia Bagni

doi:10.1016/j.cell.2014.08.035

SnapShot: FMRP mRNA targets and diseases

Cell. 2014 Sep 11;158(6):1446-1446.e1. doi: 10.1016/j.cell.2014.08.035.

Authors

Emanuela Pasciuto¹, Claudia Bagni²

Affiliations

¹ VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases (LIND), KU Leuven, 3000 Leuven, Belgium.
² VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases (LIND), KU Leuven, 3000 Leuven, Belgium; Department of Biomedicine and Prevention, University of Rome "Tor Vergata," 00133 Rome, Italy.

PMID: 25215498
DOI: 10.1016/j.cell.2014.08.035

Abstract

FMRP, or fragile X mental retardation protein is an RNA-binding protein. Mutations in the FMRP protein have been associated with neurological disease as have a number of its mRNA-binding targets. This SnapShot presents 40 bona fide FMRP targets for which mRNA binding and protein regulation have been robustly reported in mammals along with the diseases with which they have been associated.

MeSH terms

Animals
Brain Diseases / genetics*
Brain Diseases / metabolism
Fragile X Mental Retardation Protein / metabolism*
Humans
Mental Disorders / genetics*
Mental Disorders / metabolism
Neoplasms / genetics
Neoplasms / metabolism
RNA, Messenger / metabolism*

Substances

RNA, Messenger
Fragile X Mental Retardation Protein