Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

Nature. 2016 Jan 14;529(7585):226-30. doi: 10.1038/nature16527.

Abstract

Helminth parasitic infections are a major global health and social burden. The host defence against helminths such as Nippostrongylus brasiliensis is orchestrated by type 2 cell-mediated immunity. Induction of type 2 cytokines, including interleukins (IL) IL-4 and IL-13, induce goblet cell hyperplasia with mucus production, ultimately resulting in worm expulsion. However, the mechanisms underlying the initiation of type 2 responses remain incompletely understood. Here we show that tuft cells, a rare epithelial cell type in the steady-state intestinal epithelium, are responsible for initiating type 2 responses to parasites by a cytokine-mediated cellular relay. Tuft cells have a Th2-related gene expression signature and we demonstrate that they undergo a rapid and extensive IL-4Rα-dependent amplification following infection with helminth parasites, owing to direct differentiation of epithelial crypt progenitor cells. We find that the Pou2f3 gene is essential for tuft cell specification. Pou2f3(-/-) mice lack intestinal tuft cells and have defective mucosal type 2 responses to helminth infection; goblet cell hyperplasia is abrogated and worm expulsion is compromised. Notably, IL-4Rα signalling is sufficient to induce expansion of the tuft cell lineage, and ectopic stimulation of this signalling cascade obviates the need for tuft cells in the epithelial cell remodelling of the intestine. Moreover, tuft cells secrete IL-25, thereby regulating type 2 immune responses. Our data reveal a novel function of intestinal epithelial tuft cells and demonstrate a cellular relay required for initiating mucosal type 2 immunity to helminth infection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Lineage
  • Cell Proliferation
  • Feedback, Physiological
  • Female
  • Goblet Cells / cytology
  • Goblet Cells / immunology
  • Immunity, Mucosal / immunology*
  • Interleukin-13 / immunology
  • Interleukin-17 / immunology
  • Interleukin-17 / metabolism
  • Intestinal Mucosa / cytology*
  • Intestinal Mucosa / immunology*
  • Intestinal Mucosa / metabolism
  • Male
  • Mice
  • Nippostrongylus / immunology*
  • Octamer Transcription Factors / deficiency
  • Parasites / immunology*
  • Receptors, Interleukin-4 / immunology
  • Signal Transduction / immunology
  • Stem Cells / cytology
  • Stem Cells / immunology
  • Strongylida Infections / immunology
  • Th2 Cells / cytology
  • Th2 Cells / immunology

Substances

  • Interleukin-13
  • Interleukin-17
  • Octamer Transcription Factors
  • Pou2f3 protein, mouse
  • Receptors, Interleukin-4