Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

Marcel Klingenberg; Akiko Matsuda; Sven Diederichs; Tushar Patel

doi:10.1016/j.jhep.2017.04.009

Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

J Hepatol. 2017 Sep;67(3):603-618. doi: 10.1016/j.jhep.2017.04.009. Epub 2017 Apr 22.

Authors

Marcel Klingenberg¹, Akiko Matsuda², Sven Diederichs³, Tushar Patel⁴

Affiliations

¹ Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS), University of Heidelberg, Heidelberg, Germany.
² Department of Transplantation, Mayo Clinic, Jacksonville, FL, USA; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
³ Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS), University of Heidelberg, Heidelberg, Germany; German Cancer Consortium (DKTK), Freiburg, Germany; Division of Cancer Research, Dept. of Thoracic Surgery, Medical Center - University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address: s.diederichs@dkfz.de.
⁴ Department of Transplantation, Mayo Clinic, Jacksonville, FL, USA; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA. Electronic address: patel.tushar@mayo.edu.

PMID: 28438689
DOI: 10.1016/j.jhep.2017.04.009

Abstract

The majority of the human genome is not translated into proteins but can be transcribed into RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins, they contribute to diseases such as cancer. Here, we review examples of the functions of ncRNAs in liver cancer and their potential use for the detection and treatment of liver cancer.

Keywords: Cancer stem cell; Epithelial–to-mesenchymal transition; HCC; Hepatocellular carcinoma; Liver cancer; Long non-coding RNA; STAT3; Wnt; lncRNA; microRNA.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Biomarkers
Carcinoma, Hepatocellular / drug therapy
Carcinoma, Hepatocellular / genetics*
Epithelial-Mesenchymal Transition
Humans
Liver Neoplasms / drug therapy
Liver Neoplasms / genetics*
MicroRNAs / physiology
Neoplastic Stem Cells / physiology
RNA, Untranslated / physiology*
STAT3 Transcription Factor / physiology
Wnt Signaling Pathway / physiology

Substances

Biomarkers
MIRN122 microRNA, human
MicroRNAs
RNA, Untranslated
STAT3 Transcription Factor
STAT3 protein, human