Abstract
The efficacy of 1-(2,6-dimethylphenyl)-3-methyl-amidinourea hydrochloride (lidamidine HCl, WHR-1142 A) an aryl-substituted amidinourea recently synthesized, was compared with that of loperamide in 32 patients with acute diarrhoea. The results of the study show that lidamidine HCl and loperamide had comparable effects in the pharmacological treatment of acute non-specific diarrhoea. Lidamidine HCl was also shown to be well tolerated; side-effects were generally minor and self-limiting.
Publication types
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Clinical Trial
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Controlled Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Acute Disease
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Antidiarrheals / adverse effects
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Antidiarrheals / therapeutic use*
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Clinical Trials as Topic
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Diarrhea / drug therapy*
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Double-Blind Method
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Female
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Humans
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Loperamide / adverse effects
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Loperamide / therapeutic use*
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Male
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Phenylurea Compounds / adverse effects
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Phenylurea Compounds / therapeutic use*
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Piperidines / therapeutic use*
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Random Allocation
Substances
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Antidiarrheals
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Phenylurea Compounds
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Piperidines
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Loperamide
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lidamidine