Pain relief by antidepressants: possible modes of action

Charlotte Feinmann

doi:10.1016/0304-3959(85)90223-4

Pain relief by antidepressants: possible modes of action

Pain. 1985 Sep;23(1):1-8. doi: 10.1016/0304-3959(85)90223-4.

Author

Charlotte Feinmann¹

Affiliation

¹ Consultant Psychological Medicine, Eastman Dental Hospital, London WC1 U.K.

PMID: 3903613
DOI: 10.1016/0304-3959(85)90223-4

Abstract

There is evidence that both tricyclic antidepressants and monoamine oxidase inhibitors can relieve chronic pain. There are a number of possible mechanisms for this phenomenon, recent studies suggest that this may be due to an analgesic rather than antidepressant effect.

Publication types

Review

MeSH terms

Animals
Antidepressive Agents / therapeutic use*
Antidepressive Agents, Tricyclic / therapeutic use
Brain / metabolism
Depression / drug therapy
Depression / metabolism
Humans
Monoamine Oxidase Inhibitors / therapeutic use
Pain / drug therapy*
Pain / metabolism
Serotonin / metabolism

Substances

Antidepressive Agents
Antidepressive Agents, Tricyclic
Monoamine Oxidase Inhibitors
Serotonin