Abstract
Of 12 patients with inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) or sacroiliitis (SI), only 4 (32%) had HLA-B27. Family studies revealed 3 B27-negative relatives with AS, 1 with SI, 1 with SI and IBD, and 1 with IBD alone. HLA haplotypes did not segregate with disease. These data suggest a non-HLA linked genetic predisposition to IBD which also confers susceptibility to spondylitis, even in the absence of expression of bowel disease.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Arthritis / complications
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Arthritis / genetics*
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Back Pain / complications
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Colitis, Ulcerative / complications
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Colitis, Ulcerative / genetics*
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Crohn Disease / complications
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Crohn Disease / genetics*
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Disease Susceptibility
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Female
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Genotype
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HLA Antigens / analysis
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Humans
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Male
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Middle Aged
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Pedigree
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Sacroiliac Joint*
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Spondylitis, Ankylosing / complications
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Spondylitis, Ankylosing / genetics*