Abstract
We report two patients with large bowel submucosal diaphragm disease associated with nonsteroidal anti-inflammatory drugs (slow release form of diclofenac and phenylbutazone) who were admitted in 1990 and 1991 because of iron deficiency. At colonoscopy, the lumen of the ascending colon was divided into compartments by multiple thin circumferential mucosal membranes. Barium enema showed two short strictures in one patient. Right hemicolectomy was carried out on one patient. The other patient was simply advised to discontinue taking diclofenac and remains well. Such lesions are rare (10 cases have been reported) and resemble those previously described in the small bowel.
MeSH terms
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Aged
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Aged, 80 and over
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
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Colonic Diseases / chemically induced*
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Colonic Diseases / epidemiology
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Colonic Diseases / pathology
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Colonoscopy
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Constriction, Pathologic / chemically induced
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Constriction, Pathologic / epidemiology
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Constriction, Pathologic / pathology
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Delayed-Action Preparations
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Diclofenac / administration & dosage
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Diclofenac / adverse effects*
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Drug Administration Schedule
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Female
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Humans
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Male
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Osteoarthritis / drug therapy
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Phenylbutazone / administration & dosage
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Phenylbutazone / adverse effects*
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Spondylitis, Ankylosing / drug therapy
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Delayed-Action Preparations
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Diclofenac
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Phenylbutazone