Abstract
Oral exposure to lectins or the presence or absence of bacteria in the rat small intestine were shown by histological methods using anti-lectin antibodies or digoxigenin-labelled lectins to have major effects on the state of glycosylation of lumenal membranes and cytoplasmic glycoconjugates of epithelial cells. Taken together with the dramatic effects of exposure to lectins on gut function, metabolism and bacterial ecology, this can be used as a basis for new perspectives of biomedical manipulations to improve health.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Agglutinins / metabolism
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Agglutinins / pharmacology
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Animal Nutritional Physiological Phenomena
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Animals
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Antibodies
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Antigens, Surface / metabolism*
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Bacterial Physiological Phenomena*
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Carbohydrate Sequence
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Concanavalin A / metabolism
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Concanavalin A / pharmacology
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Digoxigenin
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Fucose / chemistry
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Fucose / metabolism
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Germ-Free Life
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Glycosylation / drug effects
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Intestinal Mucosa / metabolism*
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Intestine, Small / drug effects
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Intestine, Small / immunology
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Intestine, Small / microbiology*
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Intestines / ultrastructure
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Lectins / immunology
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Lectins / metabolism*
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Lectins / pharmacology*
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Membrane Glycoproteins / chemistry
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Membrane Glycoproteins / drug effects
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Membrane Glycoproteins / metabolism*
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Molecular Sequence Data
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Rabbits
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Rats
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Rats, Inbred Strains
Substances
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Agglutinins
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Antibodies
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Antigens, Surface
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Lectins
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Membrane Glycoproteins
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Concanavalin A
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Fucose
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Digoxigenin