Abstract
The development of gastrointestinal inflammation in recently generated gene-knockout mice suggests that inflammatory bowel disease in man may be caused by an inappropriate immune response to normal bacteria.
MeSH terms
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Animals
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Antigens, Bacterial
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Bacteria / immunology
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Digestive System / immunology
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Digestive System / microbiology
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Disease Models, Animal
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Humans
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Inflammatory Bowel Diseases / etiology*
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Inflammatory Bowel Diseases / genetics
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Inflammatory Bowel Diseases / immunology
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Interleukin-10 / genetics
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Interleukin-2 / genetics
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Mice
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Mice, Knockout
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Receptors, Antigen, T-Cell, alpha-beta / genetics
Substances
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Antigens, Bacterial
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Interleukin-2
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Receptors, Antigen, T-Cell, alpha-beta
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Interleukin-10