Gastrointestinal inflammation. Inflammatory bowel disease in knockout mice

Curr Biol. 1994 Mar 1;4(3):261-3. doi: 10.1016/s0960-9822(00)00060-9.

Abstract

The development of gastrointestinal inflammation in recently generated gene-knockout mice suggests that inflammatory bowel disease in man may be caused by an inappropriate immune response to normal bacteria.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Bacterial
  • Bacteria / immunology
  • Digestive System / immunology
  • Digestive System / microbiology
  • Disease Models, Animal
  • Humans
  • Inflammatory Bowel Diseases / etiology*
  • Inflammatory Bowel Diseases / genetics
  • Inflammatory Bowel Diseases / immunology
  • Interleukin-10 / genetics
  • Interleukin-2 / genetics
  • Mice
  • Mice, Knockout
  • Receptors, Antigen, T-Cell, alpha-beta / genetics

Substances

  • Antigens, Bacterial
  • Interleukin-2
  • Receptors, Antigen, T-Cell, alpha-beta
  • Interleukin-10