Abstract
Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned. This protein binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand shares homology with erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.
MeSH terms
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Amino Acid Sequence
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Anemia, Aplastic / pathology
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Animals
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Base Sequence
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Blood Platelets / cytology*
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Cell Differentiation
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Cell Division
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Cell Line
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Cloning, Molecular
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Erythropoietin / chemistry
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Humans
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Ligands
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Megakaryocytes / cytology*
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Mice
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Molecular Sequence Data
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Receptors, Immunologic / metabolism*
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Receptors, Immunologic / physiology
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Recombinant Proteins / biosynthesis
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Sequence Homology, Amino Acid
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Swine
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Thrombopoietin / chemistry
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Thrombopoietin / metabolism*
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Thrombopoietin / physiology
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Tissue Distribution
Substances
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Ligands
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Receptors, Immunologic
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Recombinant Proteins
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Erythropoietin
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Thrombopoietin