Abstract
Tight junctions create a paracellular barrier between both epithelial and endothelial cells. Recent advances have helped define their molecular composition and regulation. Studies in cultured cell lines provide new insights into how assembly and barrier properties may be controlled by signal transduction cascades.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Communication / physiology*
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Intercellular Junctions / physiology*
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Intercellular Junctions / ultrastructure*
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Membrane Proteins / biosynthesis
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Membrane Proteins / physiology
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Models, Biological
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Phosphoproteins / biosynthesis
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Phosphoproteins / physiology
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Signal Transduction
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Zonula Occludens-1 Protein
Substances
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Membrane Proteins
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Phosphoproteins
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Zonula Occludens-1 Protein