Neural and non-neural origin of calcitonin gene-related peptide (CGRP) in the gastric mucosa

G Jakab; H D Webster; I Salamon; E Mezey

doi:10.1016/0143-4179(93)90030-e

Neural and non-neural origin of calcitonin gene-related peptide (CGRP) in the gastric mucosa

Neuropeptides. 1993 Feb;24(2):117-22. doi: 10.1016/0143-4179(93)90030-e.

Authors

G Jakab¹, H D Webster, I Salamon, E Mezey

Affiliation

¹ Laboratory of Experimental Neuropathology, NINDS, National Institutes of Health, Bethesda, MD 20892.

PMID: 8459910
DOI: 10.1016/0143-4179(93)90030-e

Abstract

We have used immunohistochemistry and in situ hybridization histochemistry to visualize CGRP and the mRNA encoding the CGRP precursor in the stomach. CGRP is present in nerve fibers in the mucosa. CGRP mRNA and CGRP itself are also found in non-neural cells in the lamina propria. These cells are likely to be macrophages or B-lymphocytes.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
B-Lymphocytes / chemistry
Calcitonin Gene-Related Peptide / biosynthesis*
Gastric Mucosa / cytology
Gastric Mucosa / innervation
Gastric Mucosa / metabolism*
In Situ Hybridization
Macrophages / chemistry
Male
Nerve Fibers / chemistry*
RNA, Messenger / analysis
Rats
Rats, Sprague-Dawley

Substances

RNA, Messenger
Calcitonin Gene-Related Peptide