Abstract
A new version of in vivo ESR-CT system composed of custom-made 0.7 GHz ESR spectrometer, air-core magnet with a field-scanning coil, three field-gradient coils, and two computers enables up- and down-field, and rapid magnetic-field scanning linearly controlled by computer. 3D-pictures of distribution of nitroxide radicals injected in brains and livers of rats and mice were obtained in 1.5 min with resolution of 1 mm. We have also succeeded in obtaining spatial-time imagings of the animals.
MeSH terms
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Animals
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Brain / anatomy & histology
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Brain / metabolism
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Cyclic N-Oxides
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Electron Spin Resonance Spectroscopy / instrumentation
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Electron Spin Resonance Spectroscopy / methods*
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Free Radicals / analysis
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Free Radicals / pharmacokinetics
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Liver / anatomy & histology
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Liver / metabolism
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Male
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Mice
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Nitrogen Oxides / analysis
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Nitrogen Oxides / pharmacokinetics
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Rats
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Rats, Wistar
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Spin Labels
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Tomography / instrumentation
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Tomography / methods*
Substances
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Cyclic N-Oxides
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Free Radicals
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Nitrogen Oxides
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Spin Labels
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nitroxyl
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tempol