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Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo.
Gorsuch CL, Nemec P, Yu M, Xu S, Han D, Smith J, Lape J, van Buuren N, Ramirez R, Muench RC, Holdorf MM, Feierbach B, Falls G, Holt J, Shoop W, Sevigny E, Karriker F, Brown RV, Joshi A, Goodwin T, Tam YK, Lin PJC, Semple SC, Leatherbury N, Delaney Iv WE, Jantz D, Rhoden Smith A. Gorsuch CL, et al. Among authors: muench rc. Mol Ther. 2022 Sep 7;30(9):2909-2922. doi: 10.1016/j.ymthe.2022.05.013. Epub 2022 May 16. Mol Ther. 2022. PMID: 35581938 Free PMC article.
Targeted Long-Read Sequencing Reveals Comprehensive Architecture, Burden, and Transcriptional Signatures from Hepatitis B Virus-Associated Integrations and Translocations in Hepatocellular Carcinoma Cell Lines.
Ramirez R, van Buuren N, Gamelin L, Soulette C, May L, Han D, Yu M, Choy R, Cheng G, Bhardwaj N, Chiu J, Muench RC, Delaney WE 4th, Mo H, Feierbach B, Li L. Ramirez R, et al. Among authors: muench rc. J Virol. 2021 Sep 9;95(19):e0029921. doi: 10.1128/JVI.00299-21. Epub 2021 Jul 21. J Virol. 2021. PMID: 34287049 Free PMC article.